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KMID : 1134820230520030231
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 3 p.231 ~ p.240
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Alleviation of Intestinal Inflammation by Oral Supplementation of Unripe Apple Ethanolic Extract in Mice
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Jang Ha-Na
Bae Ui-Jin
Jang Mi
Lee Sung-Hyen
Kim Gi-Chang
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Abstract
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Procyanidin is known for its antioxidant and anti-inflammatory effects. Using HPLC analysis, we found that the content of procyanidin B2 is nine times higher in unripe apples than in ripe apples. This study, therefore, investigates the anti-inflammatory effects of unripe apple ethanol extraction (UAE) on colitis in mice. The intact intestinal epithelium is the channel for nutrient absorption and is crucial for maintaining good health. We simulated colitis in mice by inducing impairment of the intestinal epithelium-using dextran sodium sulfate. The efficacy of UAE administration for promoting intestinal injury repair in mice was studied in this animal model. We observed that UAE administration inhibited weight loss, pathological damage to the intestinal mucosal layer, and shortening of colon length. Moreover, UAE administration inhibited the increase of inflammatory cytokines in the serum and colon by inhibiting NF-κB signaling. The results that UAE contains high procyanidin and alleviates the symptoms of colitis in mice validate its use as a functional material for improving and treating symptoms of inflammatory bowel disease.
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KEYWORD
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unripe apple, inflammatory bowel disease, ulcerative colitis, dextran sulfate sodium
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